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A similar injections of a vaccine to prevent cocaine addicts have a euphoric reaction also helped them to combat addiction, according to the first successful study of this method to combat illicit drug use.

The injections did not work perfectly, but the researchers said their limited success is promising enough to suggest that this method type vaccine could be used to treat addiction in several years.

"It is a very important study. ... It clearly demonstrates that it is possible to generate vaccines that could interfere with the action of cocaine in the brain," said Dr. Nora Volkow, director of the National Institute on Drug Abuse, which funded the study.

The results come just days after the government agency announced plans to conduct the first study of an experimental vaccine against nicotine designed to help people quit smoking. NicVAX vaccine has been fueled by the Food and Drug Administration (FDA, for its acronym in English) and the research will be funded with money from the federal stimulus package.

Vaccines to combat cocaine and nicotine using the same method, stimulating the immune system to produce antibodies that adhere to drug molecules and prevent them from reaching the brain.

In the new study, the antibodies that fight the cocaine users helped to prevent them drugs take effect and caused nearly 40% of users substantially reduce their consumption or stop using cocaine, at least for a while.

With over two million consumers of the drug nationally and without a federally approved treatment, the results "good enough, better than nothing," said the lead author of the study, Dr. Thomas Kosten of Baylor University of Medicine in Houston. Kosten developed the vaccine used in the investigation.

The study was published Monday in the Archives of General Psychiatry, in its October issue.

Volkow said that the research illustrates a perspective "transformative" of drug addiction.

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